1_gd_arnold et al
2_development
3_nat-review
4_arnold_devbiol
5_szumska_gd
Arnold et al 1999
Arnold et al 2009-2
Leung at al 2003
lienkamp_pnas
Morgan et al 2009
Orsulic et al 1999
robertsondev

 

Publications

  

Nussbaum K, Burkhard SH, Ohs I, Mair F, Klose CSN, Arnold SJ, Diefenbach A, Tugues S, and Becher B (2017).Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs. J Exp Med. 2017 Jul 11. pii: jem.20162031. doi: 10.1084/jem.20162031.    

 


 

Probst S, Daza R, Bader N, Hummel JF, Weiß M, Tanriver Y, Hevner RF, Arnold SJ (2017). A Dual-Fluorescence Reporter in the Eomes Locus for Live Imaging and Medium-Term Lineage Tracing. Genesis. 2017 Jun 24. doi: 10.1002/dvg.23043.    

 


 

Kaminski MM, Tosic J, Pichler R, Arnold SJ, Lienkamp SS (2017). Engineering kidney cells: reprogramming and directed differentiation to renal tissues. Cell Tissue Res. 2017 Jul;369(1):185-197. doi: 10.1007/s00441-017-2629-5.    

 


 

Hofherr A, Busch T, Huber N, Nold A, Bohn A, Viau A, Bienaimé F, Kuehn EW, Arnold SJ, and Köttgen M (2017). Efficient genome editing of differentiated renal epithelial cells. Pflugers Arch. 2017 Feb;469(2):303-311. doi: 10.1007/s00424-016-1924-4.    

 


 

Probst S, and Arnold SJ (2017). Eomesodermin – at dawn of cell fate decisions during early embryogenesis. Curr Top Dev Biol. 2017;122:93-115. doi: 10.1016/bs.ctdb.2016.09.001    

 


 

Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ*, Lienkamp SS(2016). Direct Reprogramming of Fibroblasts into Renal Tubular Epithelial Cells by Defined Transcription Factors. Nat Cell Biol. 2016 Dec;18(12):1269-1280. doi: 10.1038/ncb3437. *corresponding authors 

 


 

Ohs I, van den Broek M, Nussbaum K, Arnold SJ, Münz C, Quezada S, Tugues S, and Becher B (2016). Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis. Nat Commun. 2016 Dec 16;7:13708. doi: 10.1038/ncomms13708.    

 


 

Mihalas AB, Elsen GE, Bedogni F, Daza RA, Ramos-Laguna KA, Arnold SJ, Hevner RF (2016). Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity. Cell Rep. 2016 Jun 28;16(1):92-105. doi: 10.1016/j.celrep.2016.05.072.    

 


 

Grahammer F, Wigge C, Schell C, Kretz O, Patrakka J, Schneider S, Klose M, Arnold SJ, Habermann A, Bräuniger R, Rinschen MM, Völker L, Bregenzer A, Rubbenstroth D, Boerries M, Kerjaschki D, Miner JH, Walz G, Benzing T, Fornoni A, Frangakis AS, and Huber TB (2016). A flexible, multi-layered protein scaffold maintains the slit in between glomerular podocytes. JCI Insight. 2016 Jun 16;1(9). pii: e86177.    

 


 

Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, and Arnold SJ (2015). Cyclin O (Ccno) functions in deuterosome-mediated centriole amplification of multiciliated cells. EMBO J. 2015 Apr 15;34(8):1078-89. doi: 10.15252/embj.201490805.    

 


 

Kuales G, Weiss M, Sedelmeier O, Pfeiffer D, and Arnold SJ (2015). A resource for the transcriptional signature of naïve trophoblast stem cells and analysis of their developmental correlate. Stem Cells Int. 2015;2015:218518. doi: 10.1155/2015/218518.    

 


 

Tsai CY, Tsai CY, Arnold SJ, and Huang GJ (2015). Adult mice deficient in hippocampal neurogenesis exhibit less susceptibility to stress. Nat Commun. 2015 Sep 29;6:8373. doi: 10.1038/ncomms9373.    

 


 

Abe P, Molnár Z, Tzeng YS, Lai DM, Arnold, SJ, and Stumm R (2015). Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Afferents and Interneurons through CXCL12 Chemokine Signaling. J Neurosci. 2015 Sep 23;35(38):13053-63. doi: 10.1523/JNEUROSCI.1488-15.2015.    

 


 

Lupar E, Brack M, Garnier L, Laffont S, Rauch K, Schachtrup K, Arnold SJ, Guéry JC, and Izcue A (2015). Eomesodermin expression in CD4+ T cells restricts peripheral FoxP3 induction. J Immunol. 2015 Nov 15;195(10):4742-52. doi: 10.4049/jimmunol.1501159.    

 


 

Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T (2014). Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 2014 Sep 15;5:4931. doi: 10.1038/ncomms5931.

 


 

Klose CS, Blatz K, d'Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, Ebert K, Arnold SJ, Diefenbach A, Palmer E, Tanriver Y (2014).The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development. Immunity. 2014 Aug 21;41(2):230-43. doi: 10.1016/j.immuni.2014.06.018.

 


 

Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M. MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis. Cell Rep. 2014 Jun 26;7(6):1779-88. doi: 10.1016/j.celrep.2014.05.029.

 


 

Vasistha NA, García-Moreno F, Arora S, Cheung AF, Arnold SJ, Robertson EJ, Molnár Z. Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain. Cereb Cortex. 2014 Jun 13. pii: bhu125.

 


 

Klose CS, Flach M, Möhle L, Rogell L, Hoyler T, Ebert K, Fabiunke C, Pfeifer D, Sexl V, Fonseca-Pereira D, Domingues RG, Veiga-Fernandes H, Arnold SJ, Busslinger M, Dunay IR, Tanriver Y, Diefenbach A. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014 Apr 10;157(2):340-56. doi: 10.1016/j.cell.2014.03.030.

 


 

Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Günther T, Arnold SJ, Schüle R. Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun. 2014;5:3174. doi: 10.1038/ncomms4174.

 


 

Pimeisl IM, Tanriver Y, Daza RA, Vauti F, Hevner RF, Arnold HH, Arnold SJ. Generation and characterization of a tamoxifen-inducible Eomes(CreER) mouse line. Genesis. 2013 Oct;51(10):725-33. doi: 10.1002/dvg.22417.

 


 

Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrualtion. Nat Cell Biol. 2011 Aug 7. doi: 10.1038/ncb2304.

 


 

Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L. Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011 Febr 1;25(3):238-250.

 


 

Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold SJ, Schäfer T, Romaker D, Schuler J, Hoff S, Powelske C, Eifler A, Krönig C, Bullerkotte A, Nitschke R, Kuehn EW, Kim E, Burkhardt H, Brox T, Ronneberger O, Gloy J, Walz G. Inversin relays Frizzled-8 signals to promote proximal pronephros development. PNAS. 2010 Nov 23; 107 (47): 20388-20393.

 


 

Hartleben B*, Gödel M*, Meyer-Schwesinger C, Liu S, Ulrich T, Köbler S, Wiech T, Grahammer F, Arnold SJ, Lindenmeyer MT, Cohen CD, Pavenstädt H, Kerjaschki D, Mizushima N, Shaw AS, Walz G, Huber TB. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest. 2010 Apr;120(4):1084-96.

 


 

Arnold SJ, Sugnaseelan J, Groszer M, Srinivas S, Robertson EJ. Generation and analysis of a mouse line harboring GFP in the Eomes/Tbr2 locus. Genesis. 2009 Nov;47(11):775-81.

 


 

Morgan MA, Magnusdottir E, Kuo TC, Tunyaplin C, Harper J, Arnold SJ, Calame K, Robertson EJ, Bikoff EK. Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation. Mol Cell Biol. 2009 Nov;29(21):5813-27.

 


 

Arnold SJ, Robertson EJ. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo.

Nat Rev Mol Cell Biol. 2009 Feb;10(2):91-103.

 


 

Arnold SJ*, Huang GJ*, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 2008 Sep 15;22(18):2479-84.

 


 

Szumska D*, Pieles G*, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 2008 Jun 1;22(11):1465-77.

 


 

Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11.

 


 

Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, Paterson C, Lejsek E, Arnold SJ, Kallies A, Nutt SL, Bikoff EK. Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development. 2007 Dec;134(24):4335-45.

 


 

Arnold SJ, Maretto S, Islam A, Bikoff EK, Robertson EJ. Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol. 2006 Aug 1;296(1):104-18.

 


 

Leung T, Söll I, Arnold SJ, Kemler R, Driever W. Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression. Dev Dyn. 2003 Nov;228(3):424-32.

 


 

Arnold SJ, Stappert J, Bauer A, Kispert A, Herrmann BG, Kemler R. Brachyury is a target gene of the Wnt/beta-catenin signaling pathway. Mech Dev. 2000 Mar 1;91(1-2):249-58.

 


 

Orsulic S, Huber O, Aberle H, Arnold S, Kemler R. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci. 1999 Apr;112 (Pt 8):1237-45.

 

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